FIG 3.

CC011 and CC074 disease outcomes after mouse-adapted SARS-CoV-2 infection. Groups of parental CC011 and CC074 mice were infected with 1 × 10⁴ PFU of SARS-CoV-2 MA10 and followed for several days for clinical disease outcomes. (A) Weight loss of the two parental CC strains CC011 and CC074. (B) Lung viral titer of the two parental CC strains CC011 and CC074 on 2 and 4 dpi. (C) Percentage survival of the two parental CC strains CC011 and CC074. (D) Lung congestion score of the two parental CC strains CC011 and CC074 (female 10- to 12-week-old mice were infected with 1 × 10⁴ PFU SARS-CoV-2 MA10; CC011: n = 6 for 2 dpi and n = 13 for 4 dpi; CC074: n = 6 for 2 dpi and n = 15 for 4 dpi, respectively). Data were analyzed using 2-way ANOVA with multiple comparison (weight and PenH), log-rank (survival), and Mann-Whitney test (lung titer and congestion scores); **, P < 0.005.