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. 2021 Sep 7;165(1):99–109. doi: 10.1111/imm.13409

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© 2021 The Authors. Immunology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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TLR stimulation alters amino acid metabolism in cDC1. (a) Metabolome view from pathway analysis performed using MetaboAnalyst in cDC1 upon poly I:C stimulation. Select pathways with high pathway impact and/or high p‐value are labelled. (b) Metabolome view from pathway analysis performed using MetaboAnalyst in cDC1 upon pRNA stimulation. Select pathways with high pathway impact and/or high p‐value are labelled. (c) Heatmap showing levels of significantly changed metabolites which regulate amino acid metabolism in cDC1 upon poly I:C stimulation for 12 h. Red colour indicates higher levels while blue colour shows lower levels. (d) Heatmap showing levels of significantly changed metabolites which regulate amino acid metabolism in cDC1 upon pRNA‐stimulation for 12 h. Red colour indicates increased levels while blue colour shows decreased levels [Colour figure can be viewed at wileyonlinelibrary.com]