TABLE 2.
List of selected pathways identified by pathway analysis in pRNA‐stimulated cDC1 using MetaboAnalyst
| No | Pathway name | Total cmpda | Hitsb | Expected | Raw p c | Holm adjust | Impactd |
|---|---|---|---|---|---|---|---|
| 1 | Aminoacyl‐tRNA biosynthesis | 75 | 15 | 0·71666 | 2·39E−18 | 1·91E−16 | 0·16902 |
| 2 | Nitrogen metabolism | 39 | 6 | 0·37266 | 1·00E−06 | 7·92E−05 | 0·00067 |
| 3 | Valine, leucine and isoleucine biosynthesis | 27 | 5 | 0·258 | 3·53E−06 | 0·00027526 | 0·06148 |
| 4 | Glycine, serine and threonine metabolism | 48 | 6 | 0·45866 | 3·57E−06 | 0·00027526 | 0·42039 |
| 5 | Cysteine and methionine metabolism | 56 | 6 | 0·53511 | 8·99E−06 | 0·00068329 | 0·07941 |
| 6 | Alanine, aspartate and glutamate metabolism | 24 | 4 | 0·22933 | 5·94E−05 | 0·004455 | 0·52897 |
| 7 | Pantothenate and CoA biosynthesis | 27 | 4 | 0·258 | 9·63E−05 | 0·0071228 | 0·18014 |
| 8 | Cyanoamino acid metabolism | 16 | 3 | 0·15289 | 0·00039387 | 0·028752 | 0 |
| 9 | Taurine and hypotaurine metabolism | 20 | 3 | 0·19111 | 0·00078201 | 0·056304 | 0·05395 |
| 10 | beta‐Alanine metabolism | 28 | 3 | 0·26755 | 0·0021377 | 0·15178 | 0 |
a
Total cmpd is the total number of compounds in the pathway.
b
Hits is the actual matched number from the uploaded data.
c
Raw p is the p‐value calculated from the pathway analysis.
d
Impact is the pathway impact value calculated from pathway topology analysis.