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. 2022 Aug 16;12:953098. doi: 10.3389/fonc.2022.953098

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Copyright © 2022 Mishra, Patil, Reddy and Lochab

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CPI444 and vatalanib-loaded GO-PEG affect the proliferation and stemness properties of GBM U87 cells. (A) Cellular calcium levels were estimated by FACS analysis using Fluo-4AM dye under different drug treatment conditions. (B) Colony forming assay of GBM U87 treated with untreated control, GO-PEG, CPI444 + vatalanib and CPI444 and vatalanib conjugated with GO-PEG. (C) Quantitation of colony forming assay, %RAU, relative absorbance units in percentage. (D) Heatmap depicting the expression levels of human pluripotent stem cell protein array for pluripotency and differentiation markers upon treatment with CPI444 and vatalanib loaded on GO-PEG with appropriate controls. MFI (Mean Fluorescence Intensity) in arbitrary units (AU); ****p <0.0001 and *p <0.05.