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. 2022 Aug 16;12:953098. doi: 10.3389/fonc.2022.953098

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Copyright © 2022 Mishra, Patil, Reddy and Lochab

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment of CPI444 and vatalanib-loaded GO-PEG inhibits the angiogenic potential and causes apoptosis of GBM U87. (A–C) A tube formation assay was performed for angiogenesis analysis in GBM cells. GBM U87 cells showed a smaller number of nodes and branches compared to control cells. (D–F) Western blot analysis of Bcl2, intact PARP, cleaved PARP. β-actin was used as an internal control. The Western blot shown is a representative of three independent experiments. ****p <0.0001, ***p <0.001, and **p <0.01.