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. 2022 Aug 15;131(6):476–491. doi: 10.1161/CIRCRESAHA.122.320888

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Expression of SIRT1 (silent information regulator 1) and SIRT1-related genes in the vascular wall of the 4 groups. A, Expression of SIRT1. B, Expression of the pro-oxidant enzyme p66^Shc. C, Expression of the antioxidant FOXO3 (Forkhead box protein O3). D, Expression of the SOD2 (superoxide dismutase-2). E, Expression of Arginase II. Results are expressed as % with respect to the Young Nonobese group. Shapiro-Wilk test was adopted to assess normality. FOXO3 and SOD2 were natural log-transformed for the means of the analyses. Young Nonobese: n=10, Old Nonobese: n=12, Young Obese: n=10, Old Obese: n=8. Data are presented as mean±SD and were compared by 2-way ANOVA followed by Holm-Sidak post hoc correction. A P<0.05 was considered significant. *P<0.05.**P<0.01. ArgII indicates Arginase II; FOXO3, Forkhead box protein O3; ON, old nonobese; OO, old obese; SOD-2, superoxide dismutase-2; YN, young nonobese; and YO, young obese.