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. 2022 Aug 15;131(6):476–491. doi: 10.1161/CIRCRESAHA.122.320888

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© 2022 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Relationship between the improvement observed with SRT1720 in ACh and L-NAME response and age, body mass index (BMI), and vascular remodeling. SRT1720 induced improvement in vasodilatory response to ACh (A–C) and inhibitory response to L-NAME (D–F) shows a direct relationship with age, BMI and M/L in the 4 groups (young nonobese: black circle, old nonobese: white circle, young obese: black triangle, old obese: white triangle; young nonobese: n=10; old nonobese: n=27; young obese: n=8; old obese: n=20). The improved response is expressed as the improvement in maximal vasodilatory response to ACh (ΔACh) or inhibitory response to L-NAME (ΔL-NAME) after SRT1720 incubation. Shapiro-Wilk test was adopted to assess normality. Linear regression was used to model the relationship between the factors. Age, BMI and M/L were used as continuous variables in the model. Data are shown unadjusted. A P<0.05 was considered significant. Ach indicates acetylcholine; and M/L, media-to-lumen ratio.