Fig. 2. SARS-CoV-2 Omicron S mutations outside the NTD and RBD.

Ribbon diagram showing a cross-section of the Omicron S glycoprotein (the location of this slice on the S trimer is indicated on the left). Mutated residues T547K, N764K, N856K, N969K, and L981F are shown as red spheres whereas the residues they contact are shown as spheres colored as the protomer they belong to. Black asterisks show the position of residues involved in the prefusion-stabilizing 2P mutations (K986P and V987P) used in all three vaccines deployed in the US. The three S protomers are colored light blue, pink or gold. N-linked glycans are shown as dark blue surfaces.