Figure 5.

Application of phage in the treatment of intestinal diseases. ① Using the nature of phage, a phage cocktail is made to target bacterial infection. ② The structure of phages can be modified by switching phage modules or by applying CRISPR gene editing technology to change the intestinal bacterial host or enhance its antagonism to the intestinal bacterial host. ③ Preparation of phage display vaccines and phage DNA vaccines to enhance specific immune responses. ④Using phage to treat specific intestinal or other bacteria with targeted delivery of disease treatment drugs. For example, glucan nanoparticles are covalently linked to azide-modified phages, polyethylene glycol capsid-modified phages, phage-liposome complexes and other anti-colorectal cancer drugs.