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. 2022 Aug 30;13:5108. doi: 10.1038/s41467-022-32565-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Four infected animals treated with FPV were early euthanized after reach of humane endpoint. a Analyze of ASAT and Cholesterol levels in plasma of treated infected animals. b Longitudinal evolution of FPV concentration and M1/FPV ratio in plasma. c Lung lesions were assessed by chest CT at 5 dpe. Overall CT score are indicated, historical untreated animal were showed in grey. Representative images of lung lesions in the four NHPs. d Liver density and volume was assessed by CT scan at 5 dpe. Values for MF18, MF22, MF25, and MF27 are indicated in color according to the FPV dose (pink: 150 mg/kg BID and yellow: 180 mg/kg BID), and other FPV treated animals were indicated in grey. Median value is indicated by horizontal bar. Source data are provided as a Source Data file. e Tissue lesions and cell infiltrates were analyzed at necropsy and histological score for lung (alveolar and vascular areas) and liver were shown for the 4 NHPs in comparison with control animals (median of n = 5). Representative images of lung (top) and liver (down) were shown. The letter E indicates presence of edema and black arrows show the neutrophilic infiltration. f Presence of SARS-CoV-2 infected cells in lung tissue was exhibited anti-Nucleocapsid antibody. Black arrows indicated infected cells. The black bars indicate 50 μm.