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. 2022 Aug 30;11:e75879. doi: 10.7554/eLife.75879

Figure 10. DamID-seq demonstrates reproducible binding of Ey and Su(H) to the slp1/2 enhancers in vivo.

Prominent reproducible peaks of Ey and Su(H) binding are seen in neighborhood of the slp1 and slp2 gene loci including at the genomic locations of identified 220 bp and 850 bp enhancers in both replicates of Ey-Dam and Su(H)-Dam experiments. Peaks at the u8772 220 bp and the d5778 850 bp enhancers have passed IDR <0.05 cut-off supporting their reproducibility.

Figure 10.

Figure 10—figure supplement 1. Examples of DamID-seq profiles on selected genes.

Figure 10—figure supplement 1.

The IDR tracks are showing peaks that have passed the IDR <0.05 cut-off. (A) IDR Peaks for Ey but not Su(H) are observed in the vicinity of the scro gene locus. (B) IDR Peaks for Ey but not Su(H) are observed within the intron of Hmx gene locus. (C) IDR Peaks for Su(H) but not Ey are observed in the dll gene locus.