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. Author manuscript; available in PMC: 2022 Aug 30.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Jan 25;107(2):299–304. doi: 10.1016/j.ijrobp.2020.01.010

A: Illustration of the study-specific dose offset, δDose, required for the control arm outcome to fall on a reference sigmoid dose-response curve with the steepness defined by meta-analysis of the normofractionated randomized dose-escalation studies.

B: Experimental arm EQD2 and control probabilities after applying δDose, Note signs of systematic deviation from sigmoid shape at high doses. Error bars show 95% CI of the bPFS estimate as detailed in Methods and Materials. Nine studies of altered fractionation and five studies of dose escalation are included. The two experimental arms by Dearnaley et al from 2016 are included as individual studies and denoted by experimental arm dose rather than date of publication.

A: Illustration of the study-specific dose offset, δDose, required for the control arm outcome to fall on a reference sigmoid dose-response curve with the steepness defined by meta-analysis of the normofractionated randomized dose-escalation studies.

B: Experimental arm EQD2 and control probabilities after applying δDose, Note signs of systematic deviation from sigmoid shape at high doses. Error bars show 95% CI of the bPFS estimate as detailed in Methods and Materials. Nine studies of altered fractionation and five studies of dose escalation are included. The two experimental arms by Dearnaley et al from 2016 are included as individual studies and denoted by experimental arm dose rather than date of publication.