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. 2022 Aug 30;2022(8):CD007697. doi: 10.1002/14651858.CD007697.pub3

Comparison 1. Ultra‐radical versus standard surgery (upfront surgery).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Survival 2 397 Hazard Ratio (IV, Random, 95% CI) 0.60 [0.43, 0.82]
1.1.1 Overall survival 1 203 Hazard Ratio (IV, Random, 95% CI) 0.56 [0.37, 0.87]
1.1.2 Disease‐specific survival 1 194 Hazard Ratio (IV, Random, 95% CI) 0.64 [0.40, 1.04]
1.2 Survival: women with carcinomatosis (upfront surgery) 2   Hazard Ratio (IV, Random, 95% CI) 0.61 [0.44, 0.85]
1.2.1 Overall survival 1   Hazard Ratio (IV, Random, 95% CI) 0.58 [0.35, 0.96]
1.2.2 Disease‐specific survival 1   Hazard Ratio (IV, Random, 95% CI) 0.64 [0.41, 0.98]
1.3 Progression‐free survival 1   Hazard Ratio (IV, Random, 95% CI) Totals not selected
1.3.1 Upfront primary debulking surgery 1   Hazard Ratio (IV, Random, 95% CI) Totals not selected
1.4 Progression‐free survival: women with carcinomatosis (upfront surgery) 1   Hazard Ratio (IV, Random, 95% CI) Subtotals only
1.5 Disease‐free survival 1 527 Hazard Ratio (IV, Random, 95% CI) 1.60 [1.11, 2.31]
1.5.1 Mix of upfront and interval debulking surgical procedures – including group 2A 1 258 Hazard Ratio (IV, Random, 95% CI) 1.54 [0.91, 2.60]
1.5.2 Mix of upfront and interval debulking surgical procedures – including group 2B 1 269 Hazard Ratio (IV, Random, 95% CI) 1.66 [1.00, 2.78]