Table 1.
Summary of cell surface phenotype, transcription factor/gene expression profiles of mouse ILC2 and ILC3 subsets.
| ILC2 and ILC3 subsets | Transcription factor and gene expression profile* | References |
|---|---|---|
| Conventional ST2+IL-18R- ILC2 (nILC2) | Gata3 high Rora + | (34, 41, 42) |
| Resident ST2- IL-18R+ ILC2 progenitors | Gata3 int Tcf7 high Rora + | (43, 44) |
| Ex-ILC2/ILC1-like cells | Gata3 int Tbx21 + | (45, 46) |
| Mixed ILC2-ILC3 like cell | Il5+Il13+Il17a+ Il22+Il23r+ | (47) |
| Inflammatory ILC2 (iILC2) | Gata3 highRORγtint Il17rb high | (48–51) |
| Memory ILC2 | Gata3 high Il17rb + | (52) |
| CCR6-NKp46- DN (precursor-like) ILC3 | RORγt+ T-bet- | (53–56) |
| Transitional DN ILC3 | RORγt+T-bet+ | (53, 55) |
| NCR+ ILC3 | RORγt+T-bet+ | (10, 57) |
| CCR6+ LTi-like ILC3 | RORγt+T-bet- | (58, 59) |
| Ex-ILC3/ILC1 | RORγt-T-bet+ | (32, 53, 54, 60) |
int – intermediate expression level.
*evidence for transcript expression in italics.