Study ID	Treatment, dose, frequency	Number of adverse events	Group total	Percentage
De Leo 2017	D‐mannose + cranberry + noxamicina (unknown doses)	0	100	0%
	No treatment	0	50	0%
Kranjcec 2014	D‐mannose 2 g Diarrhoea: 8	8	103	78%
	Nitrofurantoin 50 mg (antibiotic) Diarrhoea: 10 Nausea: 6 Headache: 3 Skin rash: 1 Vaginal burning: 9	29	103	28%
	No treatment	0	102	0%
Kuzmenko 2019	Not reported	Not reported	Not reported	Not reported
Lopes de Carvalho 2012	D‐mannose 100 mg + cranberry 40 mg + vitamin C 60 mg	Not reported	Not reported	Not reported
	Placebo	Not reported	Not reported	Not reported
Palleschi 2017	D‐mannose 500 mg + N‐acetylcysteine 100 mg + Morinda citrifolia fruit extract 300 mg	0	37	0%
	Prulifloxacin 400 mg (antibiotic)	0	38	0%
Porru 2014	D‐mannose 1 g	Not reported	Not reported	Not reported
	Trimethoprim 160 mg + sulfamethoxazole 800 mg (antibiotics)	Not reported	Not reported	Not reported
Russo 2019	Cranberry + D‐mannose + Boswellia + Curcuma + NoxamicineVR (Kistinox ActVR ) oral preparation (doses not reported)	0	20	0%
	No treatment	0	20	0%