Skip to main content
. 2022 Aug 23;2022:8035083. doi: 10.1155/2022/8035083

Figure 4.

Figure 4

circKIF4A regulates breast cancer metabolic reprogramming. (a) miR-335 expression in BC cell lines. (b) A comparison of miR-335 expression in primary BC and liver metastasis tissues as well as noncancer tissues. (c) The glucose uptake and lactate production amount were reduced after transfection with siRNA. (d) Identified miR-335-5p interacting sequences within the 3′-UTR of ALDOA and POU5F mRNAs. (e) The transfection of miR-335 mimics could remarkably suppress the mRNA expression of ALDOA/HK2 and OCT4/PKM2. (f) The introduction of miR-335 mimics decreases the protein expression of ALDOA/HK2 and OCT4/PKM2. ∗P < 0.05; ∗∗P < 0.01.