Skip to main content
. 2022 Aug 23;2022:7006281. doi: 10.1155/2022/7006281

Table 1.

The roles of exosomes in inflammation and angiogenesis following stroke.

Source Cargoes Recipient cell Target molecules/pathways Function Ref.
MSCs miR-542-3p HA1800 cells (human glial cells) TLR4 Prevent inflammatory response [63]
MSCs / Astrocytes Nrf2/NF-κB Reduce the reactive astrogliosis and inflammation [64]
BMSCs miR-138-5p Astrocytes LCN2 Inhibit inflammation [65]
Plasma miRNAs / TLR4/NF-κB Against inflammation and inflammasome-mediated pyroptosis [66]
NPCs miRNAs BV2 microglia MAPK Inhibit inflammation [67]
MSCs miR-223-3p BV2 microglia Microglial M1 polarization Inhibit inflammation [74]
hUMSCs miR-146a-5p Microglia IRAK1/TRAF6 Attenuate neuroinflammation [75]
Serum miR-27-3p Microglia PPARγ Aggravate cerebral inflammation and promote microglia activation [76]
BMSCs miR-221-3p Neurons ATF3 Attenuate neuroinflammation and apoptosis [78]
MSCs miR-29b-3p BMECs, neurons PTEN, AKT Promote angiogenesis and antiapoptosis [112]
MSCs miR-210 Cerebral vascular endothelial cells integrin β3,VEGF, CD34 Promote angiogenesis [114]
MSCs / Pheochromocytoma 12 cells, human umbilical vein endothelial cells Neuronal nitric oxide synthases, arginase-1, microtubule-associated protein 2, TNF-α, IL-1β, COX2 Enhance angiogenesis and anti-inflammatory [23]
MSCs / / / Promote angiogenesis, reduce macrophage infiltrate and microglia accumulate [115]
MSCs miRNAs BMECs VEGF, leukocyte transendothelial migration Induce angiogenesis [116]
MSCs / Endothelial cells, neuroblasts Doublecortin, von Willebrand factor Increase angiogenesis and enhance neurovascular remodeling [117]
EPCs miR-126 BMECs, neurons, astrocytes, microglia VEGFR2, caspase-3 Promote angiogenesis [122]
EPCs miR-137 SH-SY5Y cells COX2/PGE2 Against apoptosis and mitochondrial dysfunction
ADSCs miR-181b-5p BMECs TRPM7 Promote angiogenesis [126]
ADSCs miR-126 Microglia, endothelial cells TNF-α,IL-1β,von Willebrand factor Promote angiogenesis, inhibit microglial activation and inflammatory response [129]