Table 4.
Association of NLRP3 polymorphisms with clinical characteristics and risk of GA/HUA.
| Category | rs3806268 | rs3738448 | rs7525979 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GA | Control | OR (95% CI) | p value | HUA | Control | OR (95% CI) | p value | HUA | Control | OR (95% CI) | p value | |
| Obesity | ||||||||||||
| WT Ho (no) | 72 | 109 | 1.00 | 162 | 277 | 1.00 | 163 | 277 | ||||
| Ht (no) | 91 | 229 | 0.60 (0.41-0.88) | 0.0097 | 85 | 143 | 1.02 (0.73-1.42) | 0.92 | 85 | 143 | 1.01 (0.73-1.41) | 0.95 |
| VR Ho (no) | 58 | 97 | 0.91 (0.58-1.41) | 0.66 | 17 | 13 | 1.94 (0.94-3.98) | 0.072 | 16 | 15 | 1.81 (0.87-3.76) | 0.11 |
| WT Ho (yes) | 15 | 26 | 1.00 | 80 | 48 | 1.00 | 81 | 48 | 1.00 | |||
| Ht (yes) | 36 | 45 | 0.72 (0.33-1.56) | 0.4 | 24 | 22 | 0.65 (0.33-1.29) | 0.22 | 23 | 22 | 0.62 (0.31-1.23) | 0.17 |
| VR Ho (yes) | 20 | 17 | 0.49 (0.20-1.21) | 0.12 | 9 | 2 | 2.70 (0.56-13.02) | 0.18 | 9 | 2 | 2.67 (0.55-12.86) | 0.18 |
| Smoking | ||||||||||||
| WT Ho (no) | 63 | 64 | 1.00 | 145 | 181 | 1.00 | 146 | 181 | 1.00 | |||
| Ht (no) | 90 | 154 | 0.59 (0.38-0.92) | 0.018 | 63 | 100 | 0.79 (0.54-1.15) | 0.22 | 62 | 100 | 0.77 (0.52-1.13) | 0.18 |
| VR Ho (no) | 44 | 71 | 0.63 (0.38-1.05) | 0.076 | 15 | 9 | 2.08 (0.88-4.89) | 0.087 | 15 | 9 | 2.07 (0.88-4.86) | 0.09 |
| WT Ho (yes) | 35 | 60 | 1.00 | 97 | 144 | 1.00 | 98 | 144 | 1.00 | |||
| Ht (yes) | 46 | 111 | 0.71 (0.41-1.22) | 0.22 | 46 | 65 | 1.05 (0.67-1.66) | 0.83 | 46 | 65 | 1.04 (0.66-1.64) | 0.87 |
| VR Ho (yes) | 31 | 46 | 1.16 (0.62-2.14) | 0.65 | 11 | 8 | 2.04 (0.79-5.26) | 0.14 | 10 | 8 | 1.84 (0.70-4.82) | 0.21 |
| Hypertension | ||||||||||||
| WT Ho (no) | 31 | 78 | 1.00 | 100 | 188 | 1.00 | 100 | 189 | 1.00 | |||
| Ht (no) | 40 | 144 | 0.70 (0.41-1.20) | 0.2 | 41 | 98 | 0.79 (0.51-1.22) | 0.28 | 42 | 97 | 0.82 (0.53-1.27) | 0.36 |
| VR Ho (no) | 21 | 77 | 0.69 (0.36-1.30) | 0.24 | 9 | 13 | 1.30 (0.54-3.15) | 0.56 | 8 | 13 | 1.16 (0.47-2.90) | 0.75 |
| WT Ho (yes) | 67 | 46 | 1.00 | 142 | 137 | 1.00 | 144 | 136 | 1.00 | |||
| Ht (yes) | 96 | 121 | 0.54 (0.34-0.86) | 0.0093 | 68 | 67 | 0.98 (0.65-1.48) | 0.92 | 66 | 68 | 0.92 (0.61-1.38) | 0.68 |
| VR Ho (yes) | 54 | 40 | 0.93 (0.53-1.61) | 0.79 | 17 | 4 | 4.10 (1.35-12.49) | 0.0056 | 17 | 4 | 4.01 (1.32-12.23) | 0.0064 |
| Drinking | ||||||||||||
| WT ho (no) | 60 | 69 | 1.00 | 104 | 190 | 1.00 | 105 | 189 | 1.00 | |||
| Ht (no) | 91 | 160 | 0.65 (0.42-1.01) | 0.054 | 51 | 95 | 0.98 (0.65-1.49) | 0.93 | 51 | 96 | 0.96 (0.63-1.45) | 0.83 |
| VR Ho (no) | 44 | 61 | 0.83 (0.49-1.39) | 0.48 | 10 | 5 | 3.65 (1.22-10.97) | 0.016 | 9 | 5 | 3.24 (1.06-9.92) | 0.034 |
| WT Ho (yes) | 38 | 55 | 1.00 | 138 | 135 | 1.00 | 139 | 136 | 1.00 | |||
| Ht (yes) | 45 | 105 | 0.75 (0.46-1.24) | 0.28 | 58 | 70 | 0.81 (0.53-1.24) | 0.33 | 57 | 69 | 0.81 (0.53-1.23) | 0.32 |
| VR Ho (yes) | 31 | 56 | 0.80 (0.44-1.46) | 0.47 | 16 | 12 | 1.30 (0.59-2.86) | 0.51 | 16 | 12 | 1.30 (0.60-2.86) | 0.5 |
OR (95% CI) and p values were obtained from logistic regression analysis.