Table 1.
Demographic, clinical and laboratory features of patients at the time of admission and the worst results according to the maximum hepatic encephalopathy grade.
| Grade III (n = 5) |
Grade III (n = 5) |
All (n = 8) |
||||
|---|---|---|---|---|---|---|
| Median | Min, max | Median | Min, max | Median | Min, max | |
| Demographic | ||||||
| Age (years) | 36.0 | 17.0, 38.0 | 31.0 | 22.0, 47.0 | 33.5 | 17.0, 47.0 |
| Gender | ||||||
| Male | 1 | 3 | 4 | |||
| Female | 2 | 2 | 4 | |||
| Clinical | ||||||
| Fever to onset of HE (days) | 7.0 | 6.0, 13.0 | 8.0 | 5.0, 11.0 | 7.5 | 5.0, 13.0 |
| HE grade at admission | ||||||
| No HE | 1 | 2 | 3 | |||
| Grade II | 2 | 0 | 2 | |||
| Grade III | 0 | 3 | 3 | |||
| SIRS at admission | ||||||
| ≤1 | 3 | 2 | 5 | |||
| >1 | 0 | 3 | 3 | |||
| Paracetamol intake | ||||||
| Yes | 2 | 3 | 5 | |||
| No | 1 | 2 | 3 | |||
| Length of stay (days) | 10.0 | 5.0, 12.0 | 22.0 | 13.0, 35.0 | 13.5 | 5.0, 35.0 |
| Laboratory results (at admission) | ||||||
| ALT (u/L) | 1083.5 | 998.0, 1169.0 | 1311.0 | 847.0, 4161.0 | 1140.5 | 639.0, 4161.0 |
| AST (u/L) | 1781.5 | 955.0, 2608.0 | 3779.0 | 1139.0, 14,576.0 | 2777.0 | 955.0, 14,576.0 |
| ALP (u/L) | 257.5 | 161.0, 354.0 | 241.0 | 131.0, 300.0 | 241.0 | 131.0, 354.0 |
| Serum bilirubin (μmol/L) | 181.5 | 72.0, 291.0 | 67.0 | 23.0, 78.0 | 68.0 | 23.0, 291.0 |
| Serum albumin (g/L) | 26.5 | 24.0, 29.0 | 30.0 | 26.0, 35.0 | 29.0 | 24.0, 35.0 |
| PT (s) | 19.7 | 15.3, 24.0 | 16.8 | 13.3, 26.2 | 16.8 | 13.3, 26.2 |
| APTT (s) | 41.3 | 28.6, 41.3 | 39.2 | 34.2, 50.2 | 39.2 | 28.6, 50.2 |
| Fibrinogen (mg/dL) | 139.5 | 137.0, 142.0 | 230.0 | 161.0, 256.0 | 228.0 | 137.0, 256.0 |
| White cell count (103/μL) | 8.2 | 7.6, 29.9 | 19.9 | 4.6, 24.6 | 14.0 | 4.6, 29.9 |
| Haemoglobin (g/dL) | 10.2 | 10.0, 15.0 | 12.2 | 6.6, 16.5 | 11.5 | 6.6, 16.5 |
| Platelet count (103/μL) | 38.0 | 34.0, 59.0 | 62.0 | 5.0, 123.0 | 48.5 | 5.0, 123.0 |
| Haematocrit (%) | 30.7 | 29.8, 41.0 | 35.8 | 20.0, 46.0 | 33.4 | 20.0, 46.0 |
| Serum creatinine (μmol/L) | 53.0 | 40.0, 162.0 | 127.6 | 86.0, 197.0 | 107.5 | 40.0, 197.0 |
| Laboratory results (during inpatient) | ||||||
| Maximum ALT (u/L) | 1169.0 | 998.0, 1818.0 | 4089.0 | 1311.0, 5181.0 | 2487.0 | 998.0, 5181.0 |
| Maximum PT (s) | 15.3 | 15.3, 32.6 | 24.0 | 18.6, 40.7 | 22.0 | 15.3, 40.7 |
| Maximum billirubin (μmol/L) | 164.0 | 72.0, 358.0 | 90.0 | 82.0, 592.0 | 127.0 | 72.0, 592.0 |
| Minimum albumin (g/L) | 24.0 | 17.0, 24.0 | 18.0 | 16.0, 20.0 | 18.5 | 16.0, 24.0 |
| Number of days ALT ≥ 500 u/L | 4.0 | 3.0, 5.0 | 6.0 | 2.0, 9.0 | 5.5 | 2.0, 9.0 |
| Maximum creatinine (μmol/L) | 56.0 | 51.0, 162.0 | 116.0 | 86.0, 543.0 | 114.0 | 51.0, 543.0 |
Min, minimum; Max, maximum; HE, hepatic encephalopathy; SIRS, systemic inflammatory response score; ALT, alanine transaminase; AST, aspartate transaminase; ALP, alkaline phosphatase; PT, prothrombin time, control, 11.2 s; APTT, activated partial thromboplastin time, control, 33.9 s. Gender, HE grade at admission, SIRS at admission and paracetamol intake were reported in frequency.