Table 2.
Resistance pattern to first line drugs and spoligopatterns among M. tuberculosis isolates from Fortaleza, Brazil.
| Total 115 (%) |
Clustered spoligotypesa 65 (56.5%) |
Nonclustered spoligotypesa 50 (43.5%) |
p-Valueb | |
|---|---|---|---|---|
| S-TB | 64 (55.7) | 37 (56.9) | 27 (54.0) | 0.143 |
| R-TBc | 51 (44.3) | 28 (43.1) | 23 (46.0) | |
| INH | 3 (5.9) | 1 (3.6) | 2 (8.7) | |
| RMP + INH | 24 (47.1) | 12 (42.9) | 12 (52.2) | |
| RMP + INH + EMB | 12 (23.5) | 9 (32.1) | 3 (13.0) | 0.158d |
| RMP + INH + SM | 5 (9.8) | 2 (7.1) | 3 (13.0) | |
| RMP + INH + EMB + SM | 7 (13.7) | 4 (14.3) | 3 (13.0) | |
a
Clustered spoligotypes, spoligopatterns shared by two or more patients; nonclustered spoligotypes, single spoligotypes.
b
Clustered spoligotypes were taken as reference for comparison with nonclustered spoligotypes (Chi-square test).
c
INH, isoniazid; RMP, rifampicin; SM, streptomycin; EMB, ethambutol; PZA, pyrazinamide.
d
EMB resistance was compared among clustered and nonclustered spoligotypes (Fisher's exact test).