Table 1.
Summary of ceftaroline activity tested against pathogen groups from Latin America (2011).
| Organisms (no. tested) | Number of isolates (cumulative %) inhibited at ceftaroline MIC (mg/L) of: |
MIC50 | MIC90 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |||
| Staphylococcus aureus (956) | – | – | 2 (0.2) | 41 (4.5) | 489 (55.6) | 103 (66.4) | 164 (83.6) | 157 (100.0) | – | – | – | – | – | 0.25 | 2 |
| MSSA (547) | – | – | 2 (0.4) | 41 (7.9) | 485 (96.5) | 19 (100.0) | – | – | – | – | – | – | – | 0.25 | 0.25 |
| MRSA (409) | – | – | – | – | 4 (1.0) | 84 (21.5) | 164 (61.6) | 157 (100.0) | – | – | – | – | – | 1 | 2 |
| Streptococcus pneumoniae (249) | 140 (56.2) | 25 (66.3) | 22 (75.1) | 53 (96.4) | 9 (100.0) | – | – | – | – | – | – | – | – | ≤0.015 | 0.12 |
| Penicillin-susceptible (MIC, ≤2 mg/L) (215) | 140 (65.1) | 25 (76.7) | 22 (87.0) | 27 (99.5) | 1 (100.0) | – | – | – | – | – | – | – | – | ≤0.015 | 0.12 |
| Penicillin-intermediate (MIC, 4 mg/L) (33) | – | – | – | 25 (75.8) | 8 (100.0) | – | – | – | – | – | – | – | – | 0.12 | 0.25 |
| Penicillin-resistant (MIC, ≥8 mg/L) (1) | – | – | – | 1 (100.0) | – | – | – | – | – | – | – | – | – | 0.12 | – |
| S. pyogenes (66) | 65 (98.5) | 1 (100.0) | – | – | – | – | – | – | – | – | – | – | ≤0.015 | ≤0.015 | |
| S. agalactiae (78) | 71 (91.0) | 7 (100.0) | – | – | – | – | – | – | – | – | – | – | – | ≤0.015 | ≤0.015 |
| Group C Streptococcus (5) | 5 (100.0) | – | – | – | – | – | – | – | – | – | – | – | – | ≤0.015 | – |
| Haemophilus influenzae (126) | 96 (76.2) | 25 (96.0) | 3 (98.4) | 2 (100.0) | – | – | – | – | – | – | – | – | – | ≤0.015 | 0.03 |
| β-Lactamase negative (89) | 76 (85.4) | 12 (98.9) | 1 (100.0) | – | – | – | – | – | – | – | – | – | – | ≤0.015 | 0.03 |
| β-Lactamase positive (37) | 20 (54.1) | 13 (89.2) | 2 (94.6) | 2 (100.0) | – | – | – | – | – | – | – | – | – | ≤0.015 | 0.06 |
| Haemophilus parainfluenzae (6) | 5 (83.3) | 1 (100.0) | – | – | – | – | – | – | – | – | – | – | – | ≤0.015 | – |
| Escherichia coli (518) | 2 (0.4) | 41 (8.3) | 103 (28.2) | 88 (45.2) | 42 (53.3) | 18 (56.8) | 21 (60.8) | 8 (62.4) | 4 (63.1) | 6 (64.3) | 3 (64.9) | 3 (65.4) | 179 (100.0) | 0.25 | >32 |
| Non-ESBL-phenotype (323) | 2 (0.6) | 41 (13.3) | 103 (45.2) | 88 (72.4) | 42 (85.4) | 17 (90.7) | 20 (96.9) | 8 (99.4) | 1 (99.7) | 1 (100.0) | – | – | – | 0.12 | 0.5 |
| ESBL-phenotype (195) | – | – | – | – | – | 1 (0.5) | 1 (1.0) | 0 (1.0) | 3 (2.6) | 5 (5.1) | 3 (6.7) | 3 (8.2) | 179 (100.0) | >32 | >32 |
| Klebsiella pneumoniae (379) | 1 (0.3) | 13 (3.7) | 81 (25.1) | 50 (38.3) | 16 (42.5) | 8 (44.6) | 5 (45.9) | 4 (47.0) | 2 (47.5) | 4 (48.5) | 3 (49.3) | 9 (51.7) | 183 (100.0) | 32 | >32 |
| Non-ESBL-phenotype (177) | 1 (0.6) | 13 (7.9) | 81 (53.7) | 50 (81.9) | 16 (91.0) | 8 (95.5) | 5 (98.3) | 3 (100.0) | – | – | – | – | – | 0.06 | 0.25 |
| ESBL-phenotype (202) | – | – | – | – | – | – | – | 1 (0.5) | 2 (1.5) | 4 (3.5) | 3 (5.0) | 9 (9.4) | 183 (100.0) | >32 | >32 |
| Klebsiella oxytoca (40) | – | 1 (2.5) | 7 (20.0) | 9 (42.5) | 8 (62.5) | 0 (62.5) | 0 (62.5) | 0 (62.5) | 0 (62.5) | 0 (62.5) | 2 (67.5) | 1 (70.0) | 12 (100.0) | 0.25 | >32 |
| Non-ESBL-phenotype (25) | – | 1 (4.0) | 7 (32.0) | 9 (68.0) | 8 (100.0) | – | – | – | – | – | – | – | – | 0.12 | 0.25 |
| ESBL-phenotype (15) | – | – | – | – | – | – | – | – | – | – | 2 (13.3) | 1 (20.0) | 12 (100.0) | >32 | >32 |
| Morganella morganii (61) | – | 1 (1.6) | 10 (18.0) | 8 (31.1) | 7 (42.6) | 7 (54.1) | 2 (57.4) | 1 (59.0) | 3 (63.9) | 2 (67.2) | 3 (72.1) | 4 (78.7) | 13 (100.0) | 0.5 | >32 |