Table 2.

Predictors of protease inhibitor (PI), nucleoside reverse-transcriptase inhibitor (NRTI), non-nucleoside reverse-transcriptase inhibitor (NNRTI), IAS 3 class resistance, no fully susceptible drug, and genotypic susceptibility score ≥2 in treatment failing HIV-1 infected patients. Minas Gerais, Brazil, 2002–2012.

Multivariate analysis: odds ratio (95% confidence interval)
Variable (reference)	PI	NRTI	NNRTI	IAS – 3 class resistance	No fully susceptible drug	GSS ≥ 2
Year	0.88 (0.84–0.92)	–	–	0.92 (0.89–0.96)	–	1.24 (1.19–1.30)
Gender (male)	0.55 (0.44–0.69)	0.61 (0.44 – 0.83)	1.37 (1.08–1.74)	0.79 (0.64–0.97)	–	1.61 (1.3–1.99)
Age in years (>50)
<13	–	0.51 (0.23–1.13)	–	–	–	0.53 (0.35–0.82)
13–30	–	0.43 (0.23–0.79)	–	–	–	–
31–50	–	–	–	–	–	–
CD4 count/cells/μL (>500)
<201	0.5 (0.36–0.71)	0.48 (0.26–0.9)	1.47 (1.05–2.06)	–	–	–
201–500	–	0.79 (0.42–1.47)	1.23 (0.88–1.71)	–	–	–
VL at failure/copies/mL (>100,000)
<10,000	–	1.87 (1.14–3.09)	–	–	0.53 (0.34–0.84)	–
10,000–50,000	–	–	–	–	0.6 (0.39–0.91)	–
50,000–100,000	–	–	–	–	–	–
Number of regimens	–	–	–	–	–	0.73 (0.54–0.99)
Mono ZDV	2.51 (1.01–6.27)	–	–	2.16 (1.08–4.29)	2.83 (1.22–6.56)	–
ZDV + ddI	1.32 (1.01–1.73)	1.58 (1.02–2.46)	–	1.38 (1.09–1.75)	1.54 (1.08–2.2)	0.52 (0.41–0.67)
Other dual therapy	–	–	–	–	–	0.56 (0.39–0.82)
Unboosted PI	5.63 (4.41–7.2)	1.63 (1.16–2.29)	0.72 (0.55–0.95)	4.18 (3.24–5.4)	2.47 (1.6–3.83)	0.64 (0.49–0.83)
Boosted PI	1.75 (1.33–2.31)	0.44 (0.31–0.63)	–	1.58 (1.24–2)	4.4 (2.72–7.12)	0.63 (0.49–0.81)
Prior use of NNRTI	0.52 (0.4–0.68)	0.61 (0.4–0.93)	5.57 (4.39–7.08)	2.59 (2.01–3.33)	1.96 (1.33–2.9)	0.53 (0.41–0.68)
Prior use of T20	3.92 (1.47–10.43)	–	–	3.6 (1.79–7.2)	3.06 (1.61–5.8)	0.14 (0.064–0.28)
Prior use of RAL	3.69 (1.05–13.01)	–	–	–	–	–
NRTI + NNRTI in last regimen	–	–	5.99 (4.03–8.92)	0.53 (0.4–0.7)	0.44 (0.26–0.75)	–
Any PI in the last regimen	3.97 (2.98–5.29)	–	–	–	–	–