Table 2.
MiRNAs involved in CVB3infection.
| miRNA | Function | Target | Ref. |
|---|---|---|---|
| miR-146a, miR-21, miR-374, miR-29a*, miR-23a | Regulation of pathogenesis of CVB3-Induced VMC | Unknown | 48 |
| miR-342-5p | Repression of CVB3 replication | CVB3 2C-coding region | 49 |
| miR-10a* | Enhancement of viral replication | CVB3 3D-coding region | 50 |
| MiR-203 | Enhancement of viral replication | ZFP-148 | 51 |
| MiR-155 | Enhancement of myocardial inflammation response | PU.1 | 53 |
| miR-126 | Promotion of viral replication | SPRED1, LRP6, and WRCH1 | 55 |
| miR-1 | Interference of cardiac function | Cx43 | 56 |
| miR-21 | Alleviation of CVB3-induced myocarditis | PDCD4 | 57 |
| miR-21 and miR-146b | Regulation of viral pathogenesis | ROPγt | 58 |
| miR-21 | Enhancement of viral pathogenesis | YOD1 and VCL | 59 |
| miR-21 | Enhancement of viral pathogenesis | SPRY1 | 60 |
| miRNA | Verified functions of the miRNA | Verified targets | Ref. |
|---|---|---|---|
| miR-342-5p | Repression of viral replication | CVB3 2C-coding region | 38 |
| miR-10a* | Enhancement of viral replication | CVB3 3D-coding region | 39 |
| MiR-203 | Enhancement of viral replication | ZFP-148 | 40 |
| MiR-155 | Enhancement of myocardial inflammation response | PU.1 | 42 |
| miR-126 | Promotion of viral replication | SPRED1, LRP6, and WRCH1 genes | 44 |
| miR-1 | Involved in viral myocarditis | Cx43 | 45 |
| miR-21 | Alleviation of CVB3-induced myocarditis | PDCD4 | 46 |
| miR-21 and miR-124b | Regulation of viral pathogenesis | ROPγt | 47 |
| miR-21 | Enhancement of viral pathogenesis | YOD1 and VCL | 48 |
| miR-21 | Enhancement of viral pathogenesis | SPRY1 | 49 |