TABLE 1.
Baseline characteristics of UTSW-FLD patients and DHS controls
| No. | UTSW-FLD (n = 1194) | Control (n = 3120) | p-value | |
|---|---|---|---|---|
| Age, years, mean ± SD | 4314 | 54.1 ± 11.9 | 47.5 ± 11.7 | <.0001 |
| Female, N (%) | 4314 | 661 (55.4) | 1876 (60.1) | .014 |
| Race/ethnicity, N (%) | ||||
| Non-Hispanic Black | 4314 | 57 (4.8) | 1767 (56.6) | <.0001 |
| Non-Hispanic White | 4314 | 429 (35.9) | 863 (27.7) | .011 |
| Hispanic | 4314 | 668 (55.9) | 417 (13.4) | <.0001 |
| Other | 4314 | 40 (3.4) | 73 (2.3) | .143 |
| BMI, kg/m2, mean ± SD | 4314 | 32.4 ± 7.3 | 30.4 ± 7.7 | <.0001 |
| Obese, N (%) | 4314 | 717 (60.1) | 1342 (43) | <.0001 |
| Glucose, mg/dl, median (IQR) | 4138 | 111 (94–150) | 92 (85–100) | <.0001 |
| Type 2 Diabetes, N (%) | 4314 | 504 (42.2) | 391 (12.5) | <.0001 |
| Systolic BP, mmHg, mean ± SD | 4287 | 126.1 ± 16.7 | 129.7 ± 20.4 | <.0001 |
| Diastolic BP, mmHg, mean ± SD | 4287 | 71.5 ± 11.5 | 79.6 ± 9.7 | <.0001 |
| Total cholesterol, mg/dl, mean ± SD | 3963 | 162.1 ± 52.2 | 186.9 ± 38.2 | <.0001 |
| LDL-cholesterol, mg/dl, mean ± SD | 3949 | 89.2 ± 39 | 112.3 ± 34.6 | <.0001 |
| HDL-cholesterol, mg/dl, mean ± SD | 3957 | 43.4 ± 18.6 | 52.5 ± 14.7 | <.0001 |
| Triglycerides, mg/dl, median (IQR) | 3965 | 117 (82–179) | 92 (67–133) | .073 |
| ALT (U), median (IQR) | 4286 | 37 (25–60) | 17 (13–22) | <.0001 |
| AST (U), median (IQR) | 4283 | 44 (32–66) | 20 (17–24) | <.0001 |
Note: Controls were DHS participants who did not have hepatic steatosis or elevated liver enzymes. Obesity is defined as BMI ≥30kg/m2. The reported means, medians and proportions are unweighted. p-values were determined using weighted regression models.
Abbreviations: ALT, alanine aminotransaminase; AST, aspartate aminotransferase; BP, blood pressure; TG, triglyceride.