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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Thorac Oncol. 2022 Jun 24;17(9):1109–1121. doi: 10.1016/j.jtho.2022.06.004

Figure 5. POU2F3 expression in other major lung cancer types and histologic mimics of SCLC.

Figure 5.

(A) Summary of the frequency of POU2F3 expression in other major lung cancer types. *Mean (range) of POU2F3 H-score in basaloid SCC: 153 (15–275). **Mean (range) of POU2F3 H-score in LCNEC: 204 (85–300). #Lymphomas included 20 MALT lymphomas and 9 primary mediastinal B-cell lymphomas. Round cell sarcomas included 10 Ewing/Ewing family sarcomas, 7 CIC-rearranged sarcomas, 1 NCOA2-rearranged sarcoma, 1 BCOR-CCNB3 sarcoma, and 1 desmoplastic round cell tumor. (B) Illustration of representative cases of basaloid SCC (left panel) and LCNEC (right panel) with POU2F3 expression. Confirming the diagnosis of basaloid SCC is diffuse expression of p40 and the lack of NE markers. LCNEC is distinguished from SCLC based on standard morphologic criteria.

Abbreviations: LCNEC large cell neuroendocrine carcinoma, NOS, not otherwise specified, SCC squamous cell carcinoma, SMARCA4-UT SMARCA4-deficient undifferentiated tumor