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Microvascular dysfunction affecting the heart, brain, retina, lung, and kidney, representing different manifestations of small-vessel disease. They share pathophysiologic mechanisms and can occur concomitantly. ANOCA, angina with no obstructive coronary artery disease; HFpEF, heart failure with preserved ejection fraction; INOCA, ischemia with no obstructive coronary artery disease; MINOCA, myocardial infarction with no obstructive coronary arteries.
