Table 1.
Reference | Design | Objective | Population | N | Key findings |
---|---|---|---|---|---|
Argirò et al 202127 | Descriptive | Determine prevalence and severity of CMD in patients with CADASIL | CADASIL | 32 | CFR and maximal MBF following regadenason infusion were decreased in CADASIL patients compared with controls. Degree of CMD did not correlate with extent of neurologic dysfunction. |
Pai et al 200322 | Case-control | Assess brain findings in patients with CMD | CMD | 30 | High incidence of brain hypoperfusion lesions on Tc-99m ECD brain SPECT, and coincident with myocardial defects on the thallium-201 myocardial perfusion SPECT |
Brunelli et al 199625 | Descriptive | Measure cerebral blood flow and cerebrovascular vasodilator reserve in patients with CMD | CMD | 16 | Cerebral blood flow and cerebrovascular vasodilator reserve preserved in patients with CMD, not consistent with the hypothesis of a diffuse smooth‐muscle disorder |
Sun et al 200123 | Case-control | Assess brain findings in patients with CMD | CMD |
40 | 92% with definite myocardial perfusion defects on thallium‐201 myocardial perfusion SPECT also had multiple hypoperfusion areas in the brain. Parietal lobes were the most common area of hypoperfusion, cerebellum was the least common |
Karakaya et al 201124 | Cross-sectional | Investigate cerebral blood flow velocity in patients with slow coronary blood flow | Slow coronary blood flow | 32 | Right and left middle cerebral artery peak systolic, end diastolic and mean flow velocities were significantly lower in patients with slow coronary blood flow than those with normal coronary flow |
Weidmann et al 199721 | Descriptive | Investigate cerebral blood flow in patients with CMD | CMD | 95 | 76% had pathologic findings suggestive of cerebral perfusion abnormalities |
Lesnik Oberstein et al 200328 | Descriptive | Assess prevalence of myocardial ischemia in CADASIL | CADASIL | 63 | 25% of mutation carriers had ECG evidence of myocardial infarction versus none in the nonmutation carriers (p=0.011). ECG changes pre-dated neurologic symptoms of CADASIL in all patients. |
CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CFR, coronary flow reserve; CMD, coronary microvascular dysfunction; ECG, electrocardiogram; MBF, myocardial blood flow; MVD, microvascular dysfunction.