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. 2022 Aug 30;8:100. doi: 10.1038/s41523-022-00472-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Dotplot showing the twelve most significantly upregulated pathways in GPER-high and GPER-low groups from GSEA results. In the group of high GPER expression, seven of the twelve upregulated pathways are correlated with promoting tumor metastasis. b GSEA-plots showing the upregulated pro-metastatic pathways in the GPER-high group. c Heatmap for the eight most significantly upregulated pathways in GPER-high group by GSVA. Statistically significant differences were defined as adjusted P-value < 0.05.