Table 2.
Multivariate Cox regression analyses for disease-free survival and overall survival in patients with gastric cancer in the training and internal validation cohorts
| Variables | Disease-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Training cohort | ||||
| RS | 2.118 (1.478–3.035) | <0.0001 | 1.894 (1.287–2.788) | 0.001 |
| Depth of invasion | ||||
| T1 | 0.068 (0.023–0.202) | <0.0001 | 0.069 (0.020–0.232) | <0.0001 |
| T2 | 0.111 (0.035–0.358) | <0.0001 | 0.159 (0.049–0.515) | 0.002 |
| T3 | 0.233 (0.105–0.516) | <0.0001 | 0.206 (0.085–0.495) | <0.0001 |
| T4a | 0.273 (0.159–0.469) | <0.0001 | 0.258 (0.145–0.458) | <0.0001 |
| T4b | Reference | |||
| Lymph node metastasis | ||||
| N0 | 0.319 (0.165–0.616) | 0.001 | 0.286 (0.137–0.597) | 0.001 |
| N1 | 0.415 (0.229–0.753) | 0.004 | 0.296 (0.151–0.579) | <0.0001 |
| N2 | 0.289 (0.134–0.626) | 0.002 | 0.338 (0.147–0.778) | 0.011 |
| N3a | 0.551 (0.289–1.051) | 0.07 | 0.554 (0.273–1.121) | 0.1 |
| N3b | Reference | Reference | ||
| Distant metastasis | 3.621 (1.496–8.766) | 0.004 | \ | \ |
| Internal validation cohort 1 | ||||
| RS | 1.659 (1.045–2.634) | 0.032 | 1.744 (1.103–2.757) | 0.017 |
| Depth of invasion | ||||
| T1 | 0.134 (0.040–0.444) | 0.001 | 0.103 (0.027–0.388) | 0.001 |
| T2 | 0.307 (0.095–0.989) | 0.048 | 0.277 (0.088–0.868) | 0.028 |
| T3 | 0.257 (0.111–0.591) | 0.001 | 0.257 (0.111–0.594) | 0.001 |
| T4a | 0.403 (0.235–0.691) | 0.001 | 0.403 (0.228–0.713) | 0.002 |
| T4b | Reference | Reference | ||
| Lymph node metastasis | ||||
| N0 | 0.156 (0.065–0.379) | <0.0001 | 0.255 (0.103–0.634) | 0.003 |
| N1 | 0.198 (0.087–0.451) | <0.0001 | 0.253 (0.102–0.628) | 0.003 |
| N2 | 0.321 (0.150–0.689) | 0.004 | 0.396 (0.174–0.902) | 0.027 |
| N3a | 0.407 (0.191–0.869) | 0.02 | 0.586 (0.265–1.296) | 0.187 |
| N3b | Reference | Reference | ||
| Internal validation cohort 2 | ||||
| RS | 1.478 (1.209–1.806) | 0.0001 | 1.544 (1.243–1.919) | <0.0001 |
| CEA (elevated versus normal) | 1.429 (1.004–2.036) | 0.048 | 1.720 (1.161–2.546) | 0.007 |
| CA19-9 (elevated versus normal) | 1.782 (1.300–2.442) | <0.0001 | 1.598 (1.118–2.285) | 0.01 |
| Depth of invasion | ||||
| T1 | 0.148 (0.098–0.224) | <0.0001 | 0.140 (0.085–0.230) | <0.0001 |
| T2 | 0.278 (0.167–0.465) | <0.0001 | 0.373 (0.216–0.644) | <0.0001 |
| T3 | 0.427 (0.200–0.908) | 0.027 | 0.598 (0.265–1.349) | 0.215 |
| T4a | 0.405 (0.295–0.555) | <0.0001 | 0.477 (0.339–0.672) | <0.0001 |
| T4b | Reference | Reference | ||
| Distant metastasis | 2.471 (1.725–3.542) | <0.0001 | 2.080 (1.415–3.058) | <0.0001 |
P values reported are two-tailed from Cox proportional hazard regression analyses.
RS radiomics score, HR hazard ratio.