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. 2022 Aug 30;13:4501. doi: 10.1038/s41467-022-32266-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic outline of in vitro CB transformation assay. CB HSPCs were sorted, transduced with KMT2A-Aff1, and cultured on MS-5 stroma cells under lymphoid conditions. b Flow cytometry plots of KMT2A-Aff1-transformed HSPCs. c RT-PCR of IRX1 and HOXA9 in the transformed HSPCs. HOXA-type (PER-494) and IRX-type (PER-785) cell lines are shown as controls. Experiments were independently repeated three times, and representative results are shown. Source data are provided as a Source Data file.