Table 1.

Patient and disease characteristics of all muscle-invasive, non-advanced bladder cancer patients in the Netherlands diagnosed in 2018–2020, by sex

	Men		Women		Standardized differences
	N	%	N	%
All	2492	72	992	28
Age at diagnosis
0–50	40	2	25	3	0.12
51–60	225	9	103	10
61–70	623	25	244	25
71–80	957	38	331	33
> 80	647	26	289	29
Median, IQR	74	67–81	74	66–82
Age-adjusted CCI
< 2	130	5	70	7	0.17
2–3	878	35	398	40
4	570	23	198	20
5	387	16	133	13
> 5	425	17	148	15
Unknown	102	4	45	5
Performance status at diagnosis
ECOG 0	965	39	333	34	0.15
ECOG 1	370	15	133	13
ECOG 2	169	7	82	8
ECOG 3/4	50	2	31	3
Unknown	938	38	413	42
Renal function (mL/min/1.73m2)
0–39	342	14	136	14	0.05
40–59	533	21	216	22
60–79	647	26	253	26
≥ 80	636	26	251	25
Unknown	334	13	136	14
Clinical stage
T2, N0, M0	1,803	72	637	64	0.19
T3, N0, M0	552	22	259	26
T4a, N0, M0	137	5	96	10
Histology
Urothelial carcinoma	2,334	94	893	90	0.22
Squamous cell carcinoma	22	1	44	4
Adenocarcinoma	7	0	2	0
Neuro-endocrine carcinoma	96	4	29	3
Undifferentiated carcinoma	4	0	4	0
Other/undetermined	29	1	20	2

IQR  interquartile range, CCI Charlson Comorbidity Index, ECOG Eastern Cooperative Oncology Group