Table 10.

Clinicopathological relevant genetic alterations in human meningiomas

Genetic alteration	Clinicopathological significance
NF2 mutation	Convexity meningiomas, fibrous and transitional subtypes, more often CNS WHO grade 2/3
TRAF7 mutations	Secretory subtype
TERT promotor mutation	CNS WHO grade 3
SMARCE1 mutation	Clear cell subtype
BAP1 mutation	Rhabdoid and papillary subtypes
CDKNA2A/B loss	CNS WHO grade 3
H3K27me3 loss	Increased risk of recurrence
DNA methylation profiling	Methylation classes associated with increased risk of recurrence