Table 2.

Layered diagnosis with an example

Layer	Example
Layer 1 Integrated diagnosis	Diffuse astrocytoma, IDH-mutant, CNS WHO grade 2
Layer 2 Histopathological diagnosis	Diffuse astrocytoma
Layer 3 WHO grade	CNS WHO grade 2
Layer 4 Molecular genetics	IDH1 R132H-mutant, ATRX-mutant, TP53-mutant