Table 6.

Update on nomenclature of adult gliomas

WHO 2016 Classification of CNS Tumours Diffuse astrocytic and oligodendroglial tumours	WHO 2021 Classification of CNS Tumours Gliomas, glioneuronal tumours and neuronal tumours Adult-type diffuse gliomas
Diffuse astrocytoma, IDH-mutant, WHO grade II	Astrocytoma, IDH-mutant, CNS WHO grade 2
Anaplastic astrocytoma, IDH-mutant, WHO grade III	Astrocytoma, IDH-mutant, CNS WHO grade 3
Glioblastoma, IDH-mutant WHO grade IV (secondary glioblastoma)	Astrocytoma, IDH-mutant, CNS WHO grade 4
Diffuse astrocytoma, IDH-wildtype, WHO grade II*	Glioblastoma, IDH-wildtype, CNS WHO grade 4
Anaplastic astrocytoma, IDH-wildtype, WHO grade III*
Glioblastoma, IDH-wildtype, WHO grade IV (primary glioblastoma)
Oligodendroglioma, IDH-mutant and 1p/19q codeleted, WHO grade II	Oligodendroglioma, IDH-mutant and 1p/19q codeleted, CNS WHO grade 2
Anaplastic oligodendroglioma, IDH-mutant and 1p/19q codeleted WHO grade III	Oligodendroglioma, IDH-mutant and 1p/19q codeleted, CNS WHO grade 3

^*Detection of TERTp mutation, EGFR amplification, and/or +7/−10 (Table inspired by [42])