Table 2.

The conversion of ketone 1 to lactone 2 after 10 days of reaction performed in different ester solvents.

Temperature (°C)	Solvent	UHP (mg)	Lipase	Conversion after 10 days of incubation (%)
37	Ethyl acetate	10	CAL-B AR	19.5
45	Ethyl acetate	10	CAL-B AR	37.8
55	Ethyl acetate	10	CAL-B AR	47.2
55	Ethyl acetate	5	CAL-B AR	33.5
55	Ethyl acetate	20	CAL-B AR	63.6
55	Ethyl propionate	10	CAL-B AR	31.3
55	Propyl acetate	10	CAL-B AR	33.2
55	Ethyl benzoate	10	CAL-B AR	46.4
55	Methyl acetate	10	CAL-B AR	43
55	Ethyl acetate	10	RNL	0
55	Ethyl acetate	10	RAL	8.7
55	Ethyl acetate	10	CAL-B I150	31.1
55	Ethyl acetate	10	Amano PS	6.8
55	Ethyl acetate	20	CAL-B AR a	99 (3 days)
55	Ethyl acetate	20	–	0 (3 days)b
55	Ethyl acetate	0	CAL-B AR a	0 (3 days)c

^aDoubling of the amount of lipase.

^bControl without lipase.

^cControl without UHP.