Table 2.
Correlation analysis between GSDMC and relate genes and markers of immune cells in TIMER.
| Description | Gene markers | BRCA | |||||
|---|---|---|---|---|---|---|---|
| None | P | P.adjust | Purity | P | P.adjust | ||
| Cor | Cor | ||||||
| CD8 + T cell | CD8A | 0.168 | 2.05e−08*** | 2.73E−08 | 0.098 | 2.06e−03* | 0.002507826 |
| CD8B | 0.218 | 2.81e−13 | 7.15E−13 | 0.157 | 6.55e−07*** | 1.53E−06 | |
| T cell (general) | CD3D | 0.225 | 4.60e−14*** | 1.29E−13 | 0.15 | 2.05e−06*** | 3.59E−06 |
| CD3E | 0.213 | 9.85e−13*** | 2.12E−12 | 0.136 | 1.73e−05*** | 2.85E−05 | |
| CD2 | 0.24 | 7.77e−16*** | 3.11E−15 | 0.171 | 5.58e−08*** | 1.56E−07 | |
| B cell | CD19 | 0.2 | 2.24e−11*** | 3.69E−11 | 0.118 | 1.85e−04** | 0.000259 |
| CD79A | 0.194 | 8.35e−11*** | 1.30E−10 | 0.116 | 2.49e−04** | 0.000332 | |
| Monocyte | CD86 | 0.29 | 9.83e−23*** | 9.17E−22 | 0.247 | 2.48e−15*** | 2.31E−14 |
| CD115 (CSF1R) | 0.154 | 2.68e−07*** | 3.13E−07 | 0.085 | 7.38e−03* | 0.007653333 | |
| TAM | CCL2 | 0.347 | 1.92e−32*** | 5.38E−31 | 0.229 | 5.30e−22*** | 1.48E−20 |
| CD68 | 0.256 | 6.32e−18*** | 2.95E−17 | 0.216 | 6.15e−12*** | 2.87E−11 | |
| IL10 | 0.265 | 3.91e−19*** | 2.74E−18 | 0.221 | 1.69e−12*** | 9.46E−12 | |
| M1 Macrophage | INOS (NOS2) | 0.071 | 1.83e−02 | 0.0183 | 0.065 | 4.06e−02 | 0.0406 |
| IRF5 | 0.145 | 1.33e−06*** | 1.49E−06 | 0.109 | 5.76e−04** | 0.000733091 | |
| COX2 (PTGS2) | 0.238 | 1.27e−15*** | 4.45E−15 | 0.182 | 7.92e−09*** | 3.17E−08 | |
| M2 Macrophage | CD163 | 0.263 | 6.83e−19*** | 3.82E−18 | 0.224 | 8.70e−13*** | 6.09E−12 |
| VSIG4 | 0.168 | 2.15e−08*** | 2.74E−08 | 0.121 | 1.23e−04** | 0.000181263 | |
| MS4A4A | 0.205 | 6.16e−12*** | 1.08E−11 | 0.155 | 9.27e−07*** | 1.83E−06 | |
| Neutrophils | CD66b (CEACAM8) | 0.078 | 9.91e−03* | 0.0102 | 0.087 | 6.10e−03* | 0.006569231 |
| CD11b (ITGAM) | 0.21 | 2.03e−12*** | 3.79E−12 | 0.156 | 7.43e−07*** | 1.60E−06 | |
| CCR7 | 0.178 | 2.50e−09*** | 3.50E−09 | 0.095 | 2.80e−03* | 0.003266667 | |
| Naturalkiller cell | KIR2DL1 | 0.18 | 1.84e−09*** | 2.71E−09 | 0.155 | 9.81e−07*** | 1.83E−06 |
| KIR2DL3 | 0.217 | 3.34e−13*** | 7.79E−13 | 0.177 | 1.98e−08*** | 6.16E−08 | |
| KIR2DL4 | 0.321 | 1.06e−27*** | 1.48E−26 | 0.279 | 3.39e−19*** | 4.75E−18 | |
| KIR3DL1 | 0.212 | 1.12e−12*** | 2.24E−12 | 0.163 | 2.38e−07*** | 6.06E−07 | |
| KIR3DL2 | 0.232 | 6.20e−15*** | 1.93E−14 | 0.177 | 1.87e−08*** | 6.16E−08 | |
| KIR3DL3 | 0.109 | 2.96e−04** | 0.0003 | 0.09 | 4.74e−03* | 0.0053088 | |
| KIR2DS4 | 0.167 | 2.58e−08*** | 3.14E−08 | 0.133 | 2.69e−05*** | 4.18E−05 | |
| Dendritic cell | HLA-DPB1 | 0.141 | 2.83e−06*** | 3.73E−06 | 0.047 | 1.37e−01 | 0.137 |
| HLA-DQB1 | 0.185 | 6.81e−10*** | 1.04E−09 | 0.121 | 1.27e−04** | 0.000167409 | |
| HLA-DRA | 0.24 | 7.54e−16*** | 1.68E−15 | 0.17 | 7.09e−08*** | 1.37E−07 | |
| HLA-DPA1 | 0.157 | 1.68e−07*** | 2.44E−07 | 0.075 | 1.75e−02 | 0.019519231 | |
| BCDA-1 (CD1C) | 0.042 | 1.63e−01 | 0.163 | − 0.084 | 8.02e−03* | 0.0093032 | |
| BDCA-4 (NRP1) | 0.126 | 2.87e−05*** | 3.40E−05 | 0.086 | 6.65e−03* | 0.008035417 | |
| CD11c (ITGAX) | 0.247 | 8.33e−17*** | 2.20E−16 | 0.19 | 1.59e−09*** | 3.84E−09 | |
| Th1 | T-bet (TBX21) | 0.232 | 7.09e−15*** | 1.47E−14 | 0.163 | 2.24e−07*** | 3.82E−07 |
| STAT4 | 0.227 | 2.37e−14*** | 4.58E−14 | 0.17 | 7.58e−08*** | 1.37E−07 | |
| STAT1 | 0.248 | 7.94e−17*** | 2.20E−16 | 0.225 | 6.55e−13*** | 1.90E−12 | |
| IFN-γ (IFNG) | 0.292 | 4.57e−23*** | 1.89E−22 | 0.245 | 4.22e−15*** | 1.68E−14 | |
| TNF-α (TNF) | 0.281 | 2.10e−21*** | 7.61E−21 | 0.245 | 4.64e−15*** | 1.68E−14 | |
| Th2 | GATA3 | 0.498 | 4.89e−70*** | 1.42E−68 | − 0.472 | 2.37e−56*** | 6.87E−55 |
| STAT6 | 0.201 | 1.54e−11*** | 2.63E−11 | − 0.237 | 4.13e−14*** | 1.33E−13 | |
| STAT5A | 0.126 | 2.93e−05*** | 3.40E−05 | 0.068 | 3.17e−02 | 0.034048148 | |
| IL13 | 0.191 | 1.61e−10*** | 2.59E−10 | 0.157 | 6.78e−07*** | 1.09E−06 | |
| Tfh | BCL6 | 0.081 | 7.06e−03* | 0.007582963 | 0.054 | 9.08e−02 | 0.094042857 |
| IL21 | 0.213 | 1.02e−12*** | 1.85E−12 | 0.179 | 1.34e−08*** | 2.78E−08 | |
| Th17 | STAT3 | 0.127 | 2.24e−05*** | 2.82E−05 | 0.112 | 3.95e−04** | 0.000498043 |
| IL17A | 0.15 | 5.54e−07*** | 7.65E−07 | 0.129 | 4.46e−05*** | 6.81E−05 | |
| Treg | FOXP3 | 0.311 | 4.90e−26*** | 3.55E−25 | 0.254 | 4.14e−16*** | 2.00E−15 |
| CCR8 | 0.299 | 3.56e−24*** | 2.06E−23 | 0.263 | 3.71e−17*** | 2.69E−16 | |
| STAT5B | 0.095 | 1.55e−03* | 0.001728846 | − 0.123 | 1.07e−04** | 0.000147762 | |
| TGFβ (TGFB1) | 0.046 | 1.30e−01 | 0.134642857 | − 0.128 | 5.25e−05*** | 7.61E−05 | |
| T cell exhaustion | PD-1 (PDCD1) | 0.245 | 1.56e−16*** | 3.77E−16 | 0.182 | 7.80e−09*** | 1.74E−08 |
| CTLA4 | 0.344 | 5.46e−32*** | 5.28E−31 | 0.299 | 6.23e−22*** | 6.02E−21 | |
| LAG3 | 0.297 | 7.47e−24*** | 3.61E−23 | 0.26 | 8.25e−17 | 4.79E−16 | |
| TIM-3 (HAVCR2) | 0.248 | 8.13e−17*** | 2.20E−16 | 0.212 | 1.43e−11*** | 3.77E−11 | |
| GZMB | 0.361 | 3.63e−35*** | 5.26E−34 | 0.311 | 1.00e−23*** | 1.45E−22 | |
BRCA breast invasive carcinoma, TAM tumor-correlated macrophage, Tfh follicular helper T cell, Th T helper cell, Treg regulatory T cell.
Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. *P < 0.01 (1e−02); **P < 0.001 (1e−03); ***P < 0.0001 (1e−04).