Table 1.
Baseline demographic and clinical characteristics of 257 older patients with bacterial infections.
| Non-statin group (n = 167) | Statin group (n = 90) | p-Value | |
|---|---|---|---|
| Age, y | 81 (77, 85) | 83 (78, 86) | 0.228 |
| Male | 109 (65.3) | 52 (57.8) | 0.236 |
| APACHE II score | 12.0 (8.0, 15.0) | 10.5 (7.0, 15.0) | 0.238 |
| Site of infection | |||
| Pulmonary | 115 (68.9) | 66 (73.3) | 0.454 |
| Urinary tract | 10 (6.0) | 8 (8.9) | 0.385 |
| Soft tissue/skin | 8 (4.8) | 6 (6.7) | 0.570 |
| Biliary/gastrointestinal tract | 24 (14.4) | 4 (4.4) | 0.015 |
| Catheter-related infection | 6 (3.6) | 2 (2.2) | 0.717 |
| Others | 4 (2.4) | 4 (4.4) | 0.456 |
| Smoking | 16 (9.6) | 11 (12.2) | 0.510 |
| Drinking | 8 (4.8) | 4 (4.4) | 0.999 |
| Steroid treatment for more advanced septicemia | 40 (24) | 21 (23.3) | 0.911 |
| Blood culture (+) | 27 (16.2) | 10 (11.1) | 0.271 |
| Nosocomial infection | 46 (25.7) | 38 (42.2) | 0.007 |
| Body temperature | 37.2 (36.8, 38.2) | 38.0 (36.9, 38.7) | 0.001 |
| Heart rate | 84 (76, 95) | 83.5 (76, 96) | 0.670 |
| Respiratory rate | 19.7 (18, 20.4) | 19 (18, 20) | 0.393 |
| Systolic blood pressure, mmHg | 133 (118, 148) | 130 (119, 140) | 0.177 |
| Diastolic blood pressure, mmHg | 71 (64, 80) | 72 (67, 78) | 0.310 |
| Laboratory tests | |||
| WBC count, 109/L | 8.7 (5.8, 12.9) | 10.1 (7.5, 12.2) | 0.178 |
| Albumin, g/dL | 36.0 (32.7, 38.8) | 36.7 (34.2, 39.4) | 0.185 |
| Alanine aminotransferase, U/L | 22.0 (13.0, 41.0) | 25.5 (17.0, 38.0) | 0.153 |
| T Bil, μmol/L | 11.4 (8.4, 17) | 12 (7.8, 16) | 0.687 |
| TG, mmol/L | 1.0 (0.8, 1.4) | 1.0 (0.8, 1.4) | 0.490 |
| TC, mmol/L | 4.0 (3.2, 4.5) | 3.6 (3.2, 4.5) | 0.604 |
| HDL-C, mmol/L | 1.0 (0.8, 1.3) | 1.1 (0.9, 1.4) | 0.133 |
| LDL-C, mmol/L | 2.0 (1.5, 2.5) | 1.8 (1.5, 2.5) | 0.487 |
| Glucose, mmol/L | 5.2 (4.6, 6.3) | 5.2 (4.7, 6.0) | 0.933 |
| INR | 1.1 (1.0, 1.2) | 1.0 (1.0, 1.2) | 0.696 |
| Fibrinogen, g/L | 3.9 (3, 5) | 3.5 (2.9, 4.7) | 0.349 |
| APTT, g/L | 29.8 (25.6, 34.2) | 28.1 (24.5, 33.0) | 0.042 |
| Thrombin time, s | 18.2 (17.1, 19.6) | 18.2 (17.1, 19.5) | 0.895 |
| Prothrombin time, s | 12.3 (11.3, 13.3) | 12.3 (11.3, 13.3) | 0.900 |
| D-dimer, μg/L | 244.0 (132.0, 455.0) | 237.5 (129.0, 452.0) | 0.957 |
| CRP, mg/L | 43.5 (17.0, 80.2) | 34.0 (13.2, 60.6) | 0.138 |
Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; T Bil, total bilirubin; TG, triglyceride; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; INR, international normalized ratio; APTT, activated partial thromboplastin time; CRP, C-reactive protein.
Continuous variables are presented as median (interquartile range), and categorical variables are expressed as n (%).
Bold values indicate significance between the two groups, p < 0.05.