Table 3.

Variables associated with severe sepsis.

	Univariate analysisa		Multivariate analysis
	OR (95% CI)	p-Value	OR (95% CI)	p-Value
Age, years	1.02 (0.98, 1.07)	0.382
Male	1.08 (0.60, 1.95)	0.787
Statins	0.34 (0.17, 0.68)	0.002	0.28 (0.13, 0.62)	0.002
Infection at other sites	5.37 (1.25, 23.13)	0.024
SBP, mmHg	0.99 (0.97, 1.01)	0.090
DBP, mmHg	0.98 (0.95, 1.01)	0.089
Laboratory tests
Albumin, g/dL	0.88 (0.82, 0.94)	<0.001	0.91 (0.85, 0.98)	0.013
T Bil, μmol/L	1.02 (1.00, 1.03)	0.039
TG, mmol/L	2.13 (1.41, 3.22)	<0.001	2.29 (1.48, 3.55)	<0.001
TC, mmol/L	1.07 (0.82, 1.4)	0.612
Thrombin time, s	1.12 (1.01, 1.24)	0.033	1.16 (1.02, 1.30)	0.018
CRP, mg/L	1.01 (1.00, 1.01)	0.017	1.01 (0.99, 1.01)	0.096
Comorbidities
COPD	1.88 (1.04, 3.42)	0.038	2.23 (1.12, 4.45)	0.022
Chronic heart failure	2.59 (1.26, 5.32)	0.009	3.07 (1.31, 7.20)	0.010
Preadmission medication
Aspirin	0.46 (0.21, 0.99)	0.047
Spironolactone	2.82 (1.27, 6.25)	0.011
Digoxin	2.56 (1.06, 6.17)	0.036

Abbreviations: OR, odds ratio; CI, confidence interval; T Bil, total bilirubin; TG, tryglycerides; CRP, C-reactive protein; COPD, chronic obstructive pulmonary disease; SBP, systolic blood pressure; DBP diastolic blood pressure; TC, total cholesterol.

^aLogistic regression was implemented, and a backward procedure was applied to a multivariate analysis model (R² = 0.315).