Table 1.
Differential gene expressions of MAPK signaling pathway in RD cells in response to EV71 infection at 8 h and 20 h postinfection.
| Symbols | Description of genes | EV71/control (fold changes) |
|
|---|---|---|---|
| 8 h | 20 h | ||
| Akt1 | V-akt murine thymoma viral oncogene homolog 1 (AKT1) | −9.89 | −1.13 |
| Akt2 | V-akt murine thymoma viral oncogene homolog 2 (AKT2) | −3.36 | 2.66 |
| Akt3 | V-akt murine thymoma viral oncogene homolog 3 (AKT3) | −1.06 | 1.58 |
| c-Fos | c-fos proto-oncogene | 3.34 | 3.23 |
| c-Jun | c-Jun proto-oncogene | 3.19 | 5.52 |
| E2F1 | Transcription factor E2F1 (RBAP1; RBBP3; RBP3) | −3.99 | −1.17 |
| E2F2 | Transcription factor E2F2 | −1.64 | 1.55 |
| ELK1 | E twenty-six (ETS)-like transcription factor 1 | 1.19 | 2.19 |
| EGFR | Epidermal growth factor receptor | −4.78 | 1.38 |
| IFN-β | Interferon beta | 5.22 | 1.47 |
| IGF1 R | Insulin-like growth factor 1 (IGF-1), receptor (CD221; IGFR; JTK13) | −3.50 | 1.27 |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK-β; IKKB) | −3.52 | 1.33 |
| IKBKG | Inhibitor of nuclear factor kappa-B kinase subunit gamma (FIP3; IKK-γ; NEMO) | −5.76 | 1.40 |
| IL-1α | Interleukin-1 alpha | −2.60 | 1.64 |
| IL-1β | In Interleukin-1 beta | −2.20 | 1.30 |
| IL-2 | Interleukin 2 | 1.24 | 12.15 |
| IL-4 | Interleukin 4 | −3.72 | 2.39 |
| IL-6R | Interleukin 6 receptor (CD126) | −5.80 | 1.92 |
| IL-7 | Interleukin 7 | −1.65 | 1.26 |
| IL-10 | Interleukin 10 | 1.10 | 12.15 |
| IRAK1 | Interleukin-1 receptor-associated kinase 1 | −3.70 | 3.39 |
| JAK2 | Janus kinase 2 (JTK10; THCYT3) | 1.06 | −1.21 |
| MADD | MAP-kinase activating death domain | 1.57 | 1.82 |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 (MEKK 1; MAPKKK 1; SRXY6) | 2.08 | 2.25 |
| MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 (ASK1; MAPKKK5; MEKK5) | 1.30 | 2.00 |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 (MEKK7; MAPKKK 7;TAK1) | −1.13 | 1.14 |
| MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 (MLK2) | 1.48 | 4.07 |
| MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 (MEKK11; MLK3; PTK1) | 2.61 | 3.85 |
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 (MEKK14, NIK) | 6.12 | 4.09 |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 (MAPKK1; MEK1) | 1.30 | 2.46 |
| MAP2K2 | Mitogen-activated protein kinase kinase 2 (MAPKK2; MEK2) | −1.31 | 2.18 |
| MAP2K3 | Mitogen-activated protein kinase kinase 3 (MAPKK3; MEK3) | −2.29 | −1.10 |
| MAP2K4 | Mitogen-activated protein kinase kinase 4 (JNKK1; MAPKK4; MEK4) | −1.06 | 2.54 |
| MAP2K6 | Mitogen-activated protein kinase kinase 6 (MAPKK6; MEK6) | 1.58 | −1.23 |
| MAP2K7 | Mitogen-activated protein kinase kinase 7 (MAPKK7; MEK7) | −1.09 | 3.05 |
| MAPK1 | Mitogen-activated protein kinase 1 (ERK2; MAPK2; P42-MAPK) | 1.20 | 1.00 |
| MAPK3 | Mitogen-activated protein kinase 3 (ERK1; P44-MAPK) | 1.67 | 3.95 |
| MAPK8 | Mitogen-activated protein kinase 8 (JNK; JNK1; SAPK1) | 1.73 | 2.53 |
| MAPK9 | Mitogen-activated protein kinase 9 (JNK2; JNK2A; JNK2B; SAPK) | 1.02 | 2.25 |
| MAPK10 | Mitogen-activated protein kinase 10 (JNK3; SAPK1b) | 1.56 | 1.30 |
| MAPK11 | Mitogen-activated protein kinase 11 (p38-β MAPK) | 1.80 | 1.01 |
| MAPK12 | Mitogen-activated protein kinase 12 (p38-γ MAPK, ERK6) | 1.13 | −1.00 |
| MAPK13 | Mitogen-activated protein kinase 13 (p38-δ MAPK, SAPK4) | 1.52 | −1.34 |
| MAPK14 | Mitogen-activated protein kinase 14 (p38-α MAPK) | 1.15 | −1.19 |
| NF-κB1 | Nuclear factor NF-kappa-B p105 subunit (NF-kB1; NF-κB-p105; NF-κB-p50) | −4.81 | 1.18 |
| NF-κB3 | Nuclear factor NF-kappa-B p65 (RELA; NF-κB p65) | −1.35 | 2.63 |
| PI3Kα | Phosphoinositide-3-kinase, catalytic, alpha polypeptide (PI3K; p110-alpha) | −1.26 | 1.04 |
| PI3Kγ | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3CG; PI3K; PI3Kgamma) | −1.40 | 5.18 |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (P85B; p85; p85-BETA) | −2.12 | −1.20 |
| PPP3R1 | Protein phosphatase 2B regulatory subunit 1 (CALNB1; CNB1) | −1.52 | 1.94 |
| RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 (RIP; RIP1) | −2.44 | 1.24 |
| STAT1 | Signal Transducers and Activators of Transcription (CANDF7; ISGF-3; STAT91) | −6.18 | 4.04 |
| STAT5A | Signal transducer and activator of transcription 5A | −1.14 | −1.15 |
| STAT5B | Signal transducer and activator of transcription 5B | −3.17 | 1.08 |
| TGF-β1 | Transforming growth factor beta 1 (DPD1; LAP; TGFbeta) | −2.23 | −1.15 |
| TNF-α | Tumor necrosis factors | −1.97 | 2.19 |
Negative values indicate down-regulation of genes.