Figure 1.

Forest plot logistic regression analyses for odds of critical illness as a function of Z-scored CyC-production polygenic score (PGS)

All analyses were adjusted for age (except Columbia-vs-Columbia comparison), ancestry principal components, and sex. Control populations comprised either mild-moderate COVID-19-positive patients or ancestry-matched population controls. A mild-moderate COVID-19 control population was not available for the Columbia cohort. Critical illness refers to ICU admission for all analyses except for the Columbia cohort where it reflects a composite outcome of death or invasive respiratory support.