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. 2022 Aug 17;10:901320. doi: 10.3389/fcell.2022.901320

FIGURE 1.

FIGURE 1

Depletion of 19S RP subunits of the 26S proteasome in C. elegans hermaphrodites causes reduced 24 h brood and/or embryonic lethality. (A) Schematic of eukaryotic 26S proteasome and its subunits. (B) Schematic of an adult C. elegans hermaphrodite germ line (one gonad arm). (C) Average 24 h brood of C. elegans hermaphrodites RNAi-depleted of either a control gene (n = 152), any of the 19 subunits of the 19S RP (n = 10–83), or a 20S CP subunit, PBS-4 (n = 36). Brood is shown ±SEM and calculated from at least three independent trials. All RNAi conditions compared to control exhibit a p-value < 0.0001. (D) Percent of hatched (black bars) and unhatched (grey bars) progeny of hermaphrodites treated with either control(RNAi) or the indicated proteasome subunit(RNAi).