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. 2022 Aug 17;13:837680. doi: 10.3389/fphar.2022.837680

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Copyright © 2022 Seeliger, Carleo, Wendel-Garcia, Fuge, Montes-Warboys, Schuchardt, Molina-Molina and Prasse.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolites and lipids both associated with survival/composite endpoint and baseline GAP score. Kaplan-Meier curves with adjusted hazard ratios and p-values for the 7 analytes which were significantly associated with both the 2-years composite endpoint when dichotomized by median and also with Gender, Age, and Physiology (GAP) score at baseline (A). Log10 transformed analyte abundance was plotted against the resulting GAP indices at baseline as box-jitter-plots with associated Person correlation coefficients (between abundance and GAP score) and false discovery rate (B). All IPF patients of cohort 1 were included in the analysis (n = 122).