Table 3.
Bone penetration of antibiotics.
| Antibiotic | Time interval since last dose (h) | Bone/serum concentration ratio |
|---|---|---|
| Amoxycillin | 2 | 0.17–0.31 |
| Amoxycillin + clavulanate | 0.5–6 | 0.01–0.09 |
| Ampicillin | 0.25–4 | 0.11–0.71 |
| Sulbactam | 0.25–4 | 0.11–0.71 |
| Piperacillin | 1 | 0.18–0.23 |
| Tazobactam | 1 | 0.22–0.26 |
| Oxacillin | 1 | 0.11 |
| Ertapenem | 1.6–23.8 | 0.13–0.19 |
| Ceftriaxone | 0.2–8 | 0.07–0.17 |
| Cefazolin | 0.9 | 0.17 |
| Cefepime | 1–2 | 0.46–0.76 |
| Ceftazidime | 2 | 0.54 |
| Erythromycin | 0.25–2 | 0.18–0.28 |
| Azithromycin | 0.5–6.5 days | 2.5–6.3 |
| Clindamycin | 1–2 | 0.21–0.45 |
| Rifampin | 2–14 | 0.08–0.56 |
| Rifampin (osteomyelitis) | 3.5–4.5 | 0.57 |
| Tigecycline | 4–24 | 0.35–1.95 |
| Levofloxacin | 0.7–2 | 0.36–1.0 |
| Ciprofloxacin | 0.5–13 | 0.27–1.2 |
| Ciprofloxacin (osteomyelitis) | 2–4.5 | 0.42 |
| Vancomycin | 0.7–6 | 0.05–0.67 |
| Vancomycin (osteomyelitis) | 1–7 | 0.27 |
| Linezolid | 0.5–1.5 | 0.4–0.51 |
| Linezolid (osteomyelitis) | 0.9 | 0.23 |
| Daptomycin | 2 | 1.08 |
| Teicoplanin | 4–16 | 0.5–0.64 |