Table 1.
Experimental study with non-lethal sepsis in rats by KPC-producing Klebsiella pneumoniae. Monotherapy was compared with antibiotic combinations. Meropenem combined with other antibiotics besides having no benefit, positive cultures suggest an antagonistic effect.
| Rats | Positive blood culture | >103 CFU/mL in peritoneal fluid culture |
|---|---|---|
| No antibiotics | 100% | 100% |
| Meropenem | 100% | 100% |
| Gentamicin | 0 | 0 |
| Tigecycline | 0 | 67% |
| Polymyxin B | 0 | 0 |
| Polymyxin B + tigecycline | 0 | 0 |
| Gentamicin + tigecycline | 0 | 0 |
| Polymyxin B + gentamicin | 0 | 0 |
| Gentamicin + meropenem | 0 | 0 |
| Polymyxin B + meropenem | 67% | 0 |
| Tigecycline + meropenem | 33% | 0 |
| Polymyxin B + tigecycline + meropenem | 0 | 0 |
CFU/mL, colony-forming units per milliliter.