TABLE 2.
Factors (X), levels, and measured variables (Y) corresponding to the central composite or optimization design: formulations were synthesized according to the created design. Independent variables considered were: X1: the amount of solid lipid (mg) and X2: amount of surfactant (mg). Dependent variables were: Y1: particle size (nm); Y2: PDI, and Y3: Z-potential (mV). All the formulations contained 50 mg of PB.
| Run | X1 | X2 | Y1 | Y2 | Y3 |
|---|---|---|---|---|---|
| 1 | 500.0 | 700.0 | 144.2 | 0.254 | −10.3 |
| 2 | 500.0 | 700.0 | 145.6 | 0.248 | −8.31 |
| 3 | 500.0 | 700.0 | 146.0 | 0.260 | −8.95 |
| 4 | 250.0 | 900.0 | 183.3 | 0.376 | −2.14 |
| 5 | 500.0 | 700.0 | 153.9 | 0.256 | −9.35 |
| 6 | 750.0 | 500.0 | 199.2 | 0.240 | −8.53 |
| 7 | 250.0 | 500.0 | 170.8 | 0.370 | −1.10 |
| 8 | 853.6 | 700.0 | 164.1 | 0.263 | −9.22 |
| 9 | 500.0 | 417.2 | 164.5 | 0.305 | −11.2 |
| 10 | 750.0 | 900.0 | 169.7 | 0.238 | −4.76 |
| 11 | 500.0 | 700.0 | 153.3 | 0.280 | −5.12 |
| 12 | 500.0 | 982.8 | 155.4 | 0.282 | −7.43 |
| 13 | 146.4 | 700.0 | 219.2 | 0.433 | −2.74 |