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. 2022 Jul 26;219(9):e20220214. doi: 10.1084/jem.20220214

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© 2022 Miao et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — sBCMA-Fc V3 demonstrates adequate toxicity profile and on-target mechanism of action in nonhuman primates. (A) Changes in total body weight in kilograms of male (left) and female (right) cynomolgus monkey test subjects throughout the experiment and observation period. (B) Total lymphocyte counts expressed as 10⁹ cells/liter in the blood of male (left) and female (right) cynomolgus monkey test subjects. (C) Counts of CD3⁻CD19⁺ pan B lymphocytes (left) and CD3⁻CD20⁺ mature B lymphocytes in the peripheral blood of male cynomolgus monkey test subjects throughout the experimental period. (D) Counts of CD3⁻CD19⁺ pan B lymphocytes (left) and CD3⁻CD20⁺ mature B lymphocytes in the peripheral blood of male cynomolgus monkey test subjects throughout the experimental period. (E) Levels of IgM, IgA, and IgG levels in female cynomolgus monkey throughout the experimental period. Statistical analysis not applicable.