Table 1.

Calculated binding affinity and protein stability (in kcal/mol) for each BCMA mutation in cocomplex with APRIL

Residue	Original	Mutated	Δ Affinity	Δ Stability (solvated)	Total ΔG value (original/mutated)
R:16	SER	ALA	−0.13	−1.78	N/A
R:19	HIS	TYR	−3.95	−3.59	N/A
R:36	THR	ALA	−0.22	4.91	N/A
R:16 R:19 R:36	SER HIS THR	ALA TYR ALA	−5.85	−1.19	−4.333/−33.041

N/A, not applicable.