Table 2.

Calculated binding affinity and protein stability (in kcal/mol) for each BCMA mutation in cocomplex with BAFF

Residue	Original	Mutated	Δ Affinity	Δ Stability (solvated)	Total ΔG value (original/mutated)
R:36	THR	ALA	−0.14	4.98	N/A
R:19	HIS	TYR	−7.73	−7.52	N/A
R:16	SER	GLY	1.38	1.03	N/A
R:16 R:19 R:36	SER HIS THR	GLY TYR ALA	−3.55	2.8	−17.462/−19.858

N/A, not applicable.