Table 2.

Correlations in PD-L1 Nuclear Translocation.

Colon Adenocarcinoma (COAD)
	Gene Marker	PSEN1 Correlation (TIMER 2.0)			Gene Marker	PSEN1 Correlation (TIMER 2.0)		PD-L1 Correlation (TIMER 2.0)
		Purity-adjusted partial	P Value			Purity-adjusted partial	P Value	Purity-adjusted partial	P Value
		spearman's rho				spearman's rho		spearman's rho
PD-L1 Deacetylation	HDAC2	0.167	***	Nuclear PD-L1 regulated genes	NFκB1 (p50)	0.42	***	0.387	***
					NFκB2 (p52)	0.203	***	0.412	***
Endocytosis of PD-L1	Clathrin	0.491	***
	Adaptin β2 (AP2B1)	0.359	***		RELA (p65)	0.437	***	0.287	***
					RELB	0.162	**	0.309	***
					STAT3	0.469	***	0.467	***
Cytoskeleton	Vimentin	0.329	***
					JAK2	0.421	***	0.658	***
Nuclear Import	Importin α1	0.236	***		TNFα	0.217	***	0.526	***
	Importin β1	0.343	***		TRAF1	0.14	**	0.419	***
	Importin 5	0.138	**		BIRC3	0.341	***	0.656	***
	Importin 8	0.413	***		IRF2	0.382	***	0.364	***
	Importin 9	0.348	***		IRF4	0.278	***	0.547	***
	Importin 11	0.306	***		IRF5	0.13	**	0.219	***
	Transportin 1	0.478	***		IRF7	0.121	*	0.369	***
	Transportin 3	0.338	***		IRF8	0.313	***	0.319	***
					IRF9	0.368	***	0.574	***

*P < 0.05, **P < 0.01, ***P < 0.001.