Table 4.
Correlations between PSEN1 and the Gene Markers of the Immune Subsets determined by GEPIA.
| Cell Type | Gene Marker | Colon Adenocarcinoma (COAD) | Colon Tissue | ||
|---|---|---|---|---|---|
| PSEN1 Correlation (GEPIA) | PSEN1 Correlation (GEPIA) | ||||
| Correlation | P Value | Correlation | P Value | ||
| spearman's R value | spearman's R value | ||||
| T cell exhaustion | PD-1(PDCD1) | 0.22 | *** | -0.098 | 0.54 |
| CTLA4 | 0.28 | *** | -0.24 | 0.13 | |
| LAG3 | 0.23 | *** | 0.049 | 0.76 | |
| TIM-3 (HAVCR2) | 0.38 | *** | -0.25 | 0.12 | |
| Regulatory T cells | FOXP3 | 0.38 | *** | -0.15 | 0.34 |
| TGFβ (TGFB1) | 0.37 | *** | -0.36 | * | |
| IL-10 | 0.25 | *** | -0.46 | ** | |
| PTGIR | 0.26 | *** | -0.43 | ** | |
| ITGA4 | 0.45 | *** | 0.18 | 0.26 | |
| STAT5B | 0.29 | *** | -0.51 | *** | |
| CAFs | CD44 | 0.23 | *** | -0.48 | ** |
| α-SMA | 0.28 | *** | -0.52 | *** | |
| FAP | 0.2 | *** | -0.6 | *** | |
| FSP1 (S100A4) | 0.12 | * | -0.79 | *** | |
| PDGFRα | 0.38 | *** | -0.36 | * | |
| PDGFRβ | 0.36 | *** | -0.3 | 0.06 | |
*P < 0.05, **P < 0.01, ***P < 0.001.